In Silico Studies of Sesquiterpene Lactones from Vernonia amygdalina Delile on the Expression of EGFR and VEGFR as a New Anticancer Potential
نویسندگان
چکیده
Objective: To assess the inhibition activity of sesquiterpene lactones from Vernonia amygdalina Delile as a new anticancer potential on expression cancer therapeutic target-proteins, namely: epidermal growth factor receptor (EGFR), and vascular endothelial (VEGFR). Methods: The in silico screening, target‐based approach (docking) was performed by Prediction Activity Spectra for Substances (PASS) website AutoDock Vina program. target proteins model EGFR VEGFR were downloaded Research Collaboratory Structural Bioinformatics (RCSB) protein data bank (PDB) with 5HG7 4AG8 their respective codes. Results: test compounds have predicted molecular docking analysis showed strong interactions good targeted low score value Conclusion: to be used drugs through inhibitory qualities VEGFR. Key words: In silico, Sesquiterpene lactones, EGFR, VEGFR, Delile.
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ژورنال
عنوان ژورنال: Pharmacognosy Journal
سال: 2022
ISSN: ['0975-3575']
DOI: https://doi.org/10.5530/pj.2022.14.13